Tech & Innovation - March 28, 2025

Revolutionary Transplant Aims to Restart Sperm Production...

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At a tender age of 11, Jaiwen Hsu was diagnosed with osteosarcoma, a type of bone cancer. The chemotherapy treatments he received posed a risk to his future fertility. To tackle this issue, his parents enrolled him in an experimental study that collected and stored immature testicular tissue and sperm-forming stem cells. Now 26, Hsu has undergone a pioneering transplant procedure, which aims to restart sperm production. This technique has been detailed in a new paper yet to be peer-reviewed.

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Early Days and Diagnosis

Hsu, initially an active child, developed a knee pain that led to his osteosarcoma diagnosis. His parents, assuming it was a sports injury, were taken aback when they discovered it was bone cancer. The subsequent chemotherapy treatments raised concerns about Hsu's future fertility as sperm banking was not an option for him due to his prepubescent status.

The Experimental Study

In an attempt to address potential infertility, Hsu's parents enrolled him in a study that collected and stored his immature testicular tissue. This tissue contained precious sperm stem cells, which are present even before puberty. During puberty, these cells develop into sperm, a process known as spermatogenesis.

The Pioneering Transplant

At age 24, Hsu underwent a groundbreaking transplant procedure that involved injecting his stored stem cells into one of his testes. The hope is that these cells will engraft into the tubules of the testis and develop into mature sperm. However, due to the small amount of tissue collected, Hsu may still require assistive reproductive technology to start a family.

As an 11-year-old, I don't think I could quite understand the severity of having a cancer diagnosis or comprehend the idea of starting a family down the road and how important that would be, Hsu tells WIRED.